Cassino to Sesto San Giovanni trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cassino and arrive at Sesto S. Giovanni every 60 minutes on average. If travelling with Trenitalia, you need to know the Cassino to Sesto San Giovanni train schedule: the first train leaves at 05:00, while the last ride is at 17:22. A Cassino to Sesto San Giovanni train cost about 97.2 €. But how long is the train ride from Cassino to Sesto San Giovanni? Your journey takes about 6 hours on average.