Comiso to Santeramo in Colle trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Comiso and arrive at Santeramo every about 4 hours on average. If travelling with Trenitalia, you need to know the Comiso to Santeramo in Colle train schedule: the first train leaves at 07:09, while the last ride is at 18:22. A Comiso to Santeramo in Colle train cost about 79.75 €. But how long is the train ride from Comiso to Santeramo in Colle? Your journey takes about 23 hours on average.