Como to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Como S. Giovanni and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Como to Messina train schedule: the first train leaves at 07:13, while the last ride is at 19:13. A Como to Messina train cost about 110.8 €. But how long is the train ride from Como to Messina? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Como to Messina and find low cost tickets starting from 99 €!