Domodossola to Como trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Como S. Giovanni every 60 minutes on average. If travelling with Trenitalia, you need to know the Domodossola to Como train schedule: the first train leaves at 04:54, while the last ride is at 19:58. A Domodossola to Como train cost about 13.5 €. But how long is the train ride from Domodossola to Como? Your journey takes about 3 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Domodossola to Como and find low cost tickets starting from 10 €!