Empoli to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Empoli to Palermo train schedule: the first train leaves at 16:21, while the last ride is at 22:33. A Empoli to Palermo train cost about 96.0 €. But how long is the train ride from Empoli to Palermo? Your journey takes about 18 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Empoli to Palermo and find low cost tickets starting from 45 €!