Florence to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Florence to Messina train schedule: the first train leaves at 10:04, while the last ride is at 21:57. A Florence to Messina train cost about 77.0 €. But how long is the train ride from Florence to Messina? Your journey takes about 11 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Florence to Messina and find low cost tickets starting from 68 €!