Genoa to Isernia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Genova Piazza Principe and arrive at Isernia every about 2 hours on average. If travelling with Trenitalia, you need to know the Genoa to Isernia train schedule: the first train leaves at 07:05, while the last ride is at 23:53. A Genoa to Isernia train cost about 57.1 €. But how long is the train ride from Genoa to Isernia? Your journey takes about 10 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Genoa to Isernia and find low cost tickets starting from 31 €!