Guidonia to Milan trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Guidonia-Montecelio-S. Angelo and arrive at Milano Centrale every 60 minutes on average. If travelling with Trenitalia, you need to know the Guidonia to Milan train schedule: the first train leaves at 05:27, while the last ride is at 20:35. A Guidonia to Milan train cost about 51.1 €. But how long is the train ride from Guidonia to Milan? Your journey takes about 5 hours on average.