Isernia to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Mozia-Birgi every about 12 hours on average. If travelling with Trenitalia, you need to know the Isernia to Marsala train schedule: the first train leaves at 18:58, while the last ride is at 18:58. A Isernia to Marsala train cost about 71.95 €. But how long is the train ride from Isernia to Marsala? Your journey takes about 19 hours on average.