Manfredonia to Brindisi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Brindisi every about 4 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Brindisi train schedule: the first train leaves at 17:40, while the last ride is at 19:12. A Manfredonia to Brindisi train cost about 11.8 €. But how long is the train ride from Manfredonia to Brindisi? Your journey takes about 3 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Manfredonia to Brindisi and find low cost tickets starting from 12 €!