Manfredonia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Syracuse train schedule: the first train leaves at 17:40, while the last ride is at 17:40. A Manfredonia to Syracuse train cost about 116.5 €. But how long is the train ride from Manfredonia to Syracuse? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Manfredonia to Syracuse and find low cost tickets starting from 94 €!