Messina to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Alessandria every about 3 hours on average. If travelling with Trenitalia, you need to know the Messina to Alessandria train schedule: the first train leaves at 16:40, while the last ride is at 22:10. A Messina to Alessandria train cost about 109.45 €. But how long is the train ride from Messina to Alessandria? Your journey takes about 18 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Messina to Alessandria and find low cost tickets starting from 77 €!