Milan to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Milan to Messina train schedule: the first train leaves at 08:15, while the last ride is at 22:15. A Milan to Messina train cost about 108 €. But how long is the train ride from Milan to Messina? Your journey takes about 14 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Milan to Messina and find low cost tickets starting from 29 €! If you need to travel this week, prices start from 99€.