Milan to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Milan to Messina train schedule: the first train leaves at 08:15, while the last ride is at 22:15. A Milan to Messina train cost about 107.90 €. But how long is the train ride from Milan to Messina? Your journey takes about 14 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Milan to Messina and find low cost tickets starting from 39 €!