Molfetta to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Molfetta and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Molfetta to Comiso train schedule: the first train leaves at 18:11, while the last ride is at 21:28. A Molfetta to Comiso train cost about 63.95 €. But how long is the train ride from Molfetta to Comiso? Your journey takes about 10 hours on average.