Monopoli to Rome trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Roma Termini every about 2 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Rome train schedule: the first train leaves at 06:23, while the last ride is at 23:27. A Monopoli to Rome train cost about 52.1 €. But how long is the train ride from Monopoli to Rome? Your journey takes about 6 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Monopoli to Rome and find low cost tickets starting from 16 €!