Sant'Antonio to Perugia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Antonio Mantovano and arrive at Perugia every 60 minutes on average. If travelling with Trenitalia, you need to know the Sant'Antonio to Perugia train schedule: the first train leaves at 06:35, while the last ride is at 18:10. A Sant'Antonio to Perugia train cost about 25.35 €. But how long is the train ride from Sant'Antonio to Perugia? Your journey takes about 6 hours on average.