Segrate to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Messina train schedule: the first train leaves at 07:15, while the last ride is at 21:30. A Segrate to Messina train cost about 83.8 €. But how long is the train ride from Segrate to Messina? Your journey takes about 15 hours on average.