Sesto San Giovanni to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Salerno and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Messina train schedule: the first train leaves at 22:01, while the last ride is at 22:01. A Sesto San Giovanni to Messina train cost about 76.6 €. But how long is the train ride from Sesto San Giovanni to Messina? Your journey takes about 8 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sesto San Giovanni to Messina and find low cost tickets starting from 12 €!