Sienna to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Caltanissetta Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Sienna to Caltanissetta train schedule: the first train leaves at 18:43, while the last ride is at 18:43. A Sienna to Caltanissetta train cost about 130.4 €. But how long is the train ride from Sienna to Caltanissetta? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Caltanissetta and find low cost tickets starting from 79 €!