Syracuse to Rome trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siracusa and arrive at Roma Termini every about 2 hours on average. If travelling with Trenitalia, you need to know the Syracuse to Rome train schedule: the first train leaves at 19:10, while the last ride is at 21:45. A Syracuse to Rome train cost about 95.1 €. But how long is the train ride from Syracuse to Rome? Your journey takes about 12 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Syracuse to Rome and find low cost tickets starting from 38 €!