Varese to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Varese and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Varese to Messina train schedule: the first train leaves at 15:36, while the last ride is at 17:36. A Varese to Messina train cost about 173.4 €. But how long is the train ride from Varese to Messina? Your journey takes about 14 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Varese to Messina and find low cost tickets starting from 51 €!