Milan to Rome trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Roma Termini every 20 minutes on average. If travelling with Trenitalia, you need to know the Milan to Rome train schedule: the first train leaves at 05:42, while the last ride is at 22:15. A Milan to Rome train cost about 29.90 €. But how long is the train ride from Milan to Rome? Your journey takes about 4 hours on average. Trenitalia offers 36 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Milan to Rome and find low cost tickets starting from 19 €! When booking your train ticket a few weeks in advance though, you can find low cost trains from Milan to Rome with fares starting from 29.90€, saving up to 51%.