Milan to Genoa trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Genova Piazza Principe every about 2 hours on average. If travelling with Trenitalia, you need to know the Milan to Genoa train schedule: the first train leaves at 06:25, while the last ride is at 20:25. A Milan to Genoa train cost about 13.45 €. But how long is the train ride from Milan to Genoa? Your journey takes about 2 hours on average. Trenitalia offers 7 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Milan to Genoa and find low cost tickets starting from 9 €!